Endocrine Abstracts

Introduction: Excess GH in acromegaly has lipolytic action and detrimental effect on glucose metabolism and insulin signaling. Recent studies have suggested a specific lipodystrophy in patients with acromegaly. Paradoxically, although the visceral adipose tissue (VAT) and intrahepatic lipid were reduced in active acromegaly compared to controls, insulin resistance was increased. Fat was redistributed from subcutaneous and visceral depots to muscle; weight and VAT depots rose w...

Introduction: Pegvisomant (PEG) is an efficient treatment for acromegaly but the recommendation for this treatment is less active due to its high cost. In Romania it is reimbursed in doses up to 30 mg s.c/day or as 40 or 80 mg/week in combination with a somatostatin analog (SSA).Design: Retrospective analysis of 18 consecutive patients treated with PEG for acromegaly (either as monotherapy, or in combination with SSA and/or cabergoline (CAB...

Introduction: Pheochromocytoma (PCC) has a wide spectrum of clinical manifestations, from insidious disease to extreme symptoms. Various mechanisms of catecholamine and other mediators actions were related to the diversity of PCC presentation.Aim: We describe a retrospective study, of patients with PCC from a tertiary hospital, focusing on clinical and biochemical characteristics of PCC depending on means of discovery.Material and ...

BIOMAT-ENDO software is a Windows Forms application that stores all the main data regarding the patients with thyroid cancer (TC) hospitalized in the Nuclear Medicine Department of the National Institute of Endocrinology in Bucharest, starting with the first hospitalization, continuing with the periods of radioiodine therapy (RIT) and the follow up. Patient-monitoring MODULE contains clinical parameters, surgery details, in Vivo and in Vitro investig...

BackgroundLymphocytic hypophysitis is an unusual inflammation of the pituitary gland affecting mostly women. Its pathogenesis is still poorly understood and the presentation and clinical course vary largely. Serum prolactin levels may be low, normal, or elevated. Unlike what is observed in clinically nonfunctioning pituitary adenomas, there is not a clear hierarchy of anterior pituitary hormone deficiencies. Hypophysitismay resolve spontaneously, may rel...

IntroductionThyrotoxicosis debuted early after thyroid lobectomy is described in approximately 54% of cases. It has also been described in a few case reports after non thyroid neck surgeries or in invasive laryngeal cancer after total laryngectomy and debulking hemithyroidectomy.Case presentationPatient aged 53 years old, known with laryngeal carcinoma of 37/28/40 mm located at piriform sinus, linked by the l...

Introduction: SOX2 is an early developmental transcription factor and a marker for pituitary progenitor cells.The study aimed to investigate if the pituitary adenomas with positive SOX2 immunoreactivity shows a different response to therapy as compared with controls.Patients and methods: We investigated 15 pituitary macroadenomas, eight with SOX2 immunoreactivity (SOX2+) and seven without (SOX2−) (controls); five were GH prod...